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KMID : 0381120230450091179
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Genes and Genomics
2023 Volume.45 No. 9 p.1179 ~ p.1186
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Correlation between obstructive sleep apnea and cerebral small vessel disease: a mendelian randomization study
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Bing Wu
Fang Liu
Guiyan Sun
Shuang Wang
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Abstract
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Background : Whether obstructive sleep apnea (OSA) is causally associated with an increased risk of cerebral small vessel disease (CSVD) remains controversial. We conducted a two-sample Mendelian randomization (MR) study to clarify the causal relationship between OSA and CSVD risk.
Methods : Single-nucleotide polymorphisms associated with OSA at the genome-wide significance level (P?
Results : Genetically predicted OSA was not associated with LIs (odds ratio [OR]?=?1.10, 95% confidence interval [CI]?=?0.86?1.40), WMHs (OR?=?0.94, 95% CI?=?0.83?1.07), FA (OR?=?1.33, 95% CI?=?0.75?2.33), MD (OR?=?0.93, 95% CI?=?0.58?1.47), CMBs (OR?=?1.29, 95% CI?=?0.86?1.94), mixed CMBs (OR?=?1.17, 95% CI?=?0.63?2.17), and lobar CMBs (OR?=?1.15, 95% CI?=?0.75?1.76) in IVW method. The results of the sensitivity analyses were generally consistent with the major analyses.
Conclusions : This MR study does not support causal associations between OSA and the risk of CSVD in individuals of European ancestry. These findings need to be further validated in randomized controlled trials, larger cohort studies, and MR studies based on larger GWASs.
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KEYWORD
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Obstructive sleep apnea, Cerebral small vessel disease, Mendelian randomization, Neuroimaging, Risk factor, Epidemiology
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